항암면역치료를 위한 바이오/면역공학
면역기전 조절 물질의공학적 설계
약물전달시스템의 공학적 설계
학력
(Ph.D.) KAIST, 생명화학공학과, 2002
(M.S.) KAIST, 화학공학과, 1998
(B.S.) 서강대학교 화학공학과, 1996
약력/경력
2014-현재 교수, 성균관대학교, 성균나노과학기술원(SAINT)/나노공학과/화학공학과
2009-2013 부교수, 충남대학교 분석과학기술학과(GRAST)
2005-2009 선임연구원, 한국생명공학연구원 바이오나노연구센터
2003-2004 선임연구원, 한국전자통신연구원 바이오소자팀
2002-2003 박사후 연구원, 하버드 의과대학 혈액종양 내과
학술지 논문
(2025)
Multiscale dynamic immunomodulation by a nanoemulsified Trojan-TLR7/8 adjuvant for robust protection against heterologous pandemic and endemic viruses.
CELLULAR & MOLECULAR IMMUNOLOGY.
22,
9
(2025)
γδ+ T-cell-derived IL-17A stimulates airway epithelial/stromal cells to secrete G-CSF, promoting lung-specific pathogenic Siglec-F+ neutrophil development in PPE-induced emphysema.
CELLULAR & MOLECULAR IMMUNOLOGY.
22,
7
(2025)
Kinetically activating nanovaccine mimicking multidimensional immunomodulation of natural infection for broad protection against heterologous viruses in animal models.
NATURE COMMUNICATIONS.
16,
1
(2025)
Spatiotemporal Dynamic Immunomodulation by Infection-Mimicking Gels Enhances Broad and Durable Protective Immunity Against Heterologous Viruses.
ADVANCED SCIENCE.
(2024)
STING-activating dendritic cell-targeted nanovaccines that evoke potent antigen cross-presentation for cancer immunotherapy.
BIOACTIVE MATERIALS.
42,
(2024)
Virulence-Free Reconstituted Synthetic Nanopathogen Empowered by Timely-Activating TLR Agonist Promotes Heterologous Cancer Immunotherapy with Depletion of Tumor-Specific Treg Cells.
ADVANCED FUNCTIONAL MATERIALS.
35,
1
(2024)
3D Scaffold-Based Culture System Enhances Preclinical Evaluation of Natural Killer Cell Therapy in A549 Lung Cancer Cells.
ACS Applied Bio Materials.
7,
11
(2024)
Transformable Gel-to-Nanovaccine Enhances Cancer Immunotherapy via Metronomic-Like Immunomodulation and Collagen-Mediated Paracortex Delivery.
ADVANCED MATERIALS.
36,
48
(2024)
A biospecies-derived genomic DNA hybrid gel electrolyte for electrochemical energy storage.
PNAS NEXUS.
3,
6
(2024)
Bioconjugated Antibody-Trojan Immune Converter Enhance Cancer Immunotherapy with Minimized Toxicity by Programmed Two-Step Immunomodulation of Myeloid Cells.
ADVANCED HEALTHCARE MATERIALS.
13,
27
(2024)
Molecular Masking of Synthetic Immunomodulator Evokes Antitumor Immunity With Reduced Immune Tolerance and Systemic Toxicity by Temporal Activity Recovery and Sustained Stimulation.
ADVANCED MATERIALS.
36,
9
(2023)
Nanoengineered Macrophages Armed with TLR7/8 Agonist Enhance Remodeling of Immunosuppressive Tumor Microenvironment.
SMALL.
20,
13
(2023)
ProLonged Liposomal Delivery of TLR7/8 Agonist for Enhanced Cancer Vaccine.
VACCINES.
11,
9
(2023)
Kinetics reshape antitumor immunity: Timing, duration, and combination are of importance for successful cancer immunotherapy.
CLINICAL AND TRANSLATIONAL MEDICINE.
13,
9
(2023)
Discovery of highly immunogenic spleen-resident FCGR3(+)CD103(+) cDC1s differentiated by IL-33-primed ST2(+) basophils.
CELLULAR & MOLECULAR IMMUNOLOGY.
20,
7
(2023)
Nanoengineered drug delivery in cancer immunotherapy for overcoming immunosuppressive tumor microenvironment.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH.
13,
7
(2023)
Discovery of highly immunogenic spleen-resident FCGR3+CD103+ cDC1s differentiated by IL-33-primed ST2+ basophils.
CELLULAR & MOLECULAR IMMUNOLOGY.
20,
7
(2023)
Protective Efficacy and Immunogenicity of Rv0351/Rv3628 Subunit Vaccine Formulated in Different Adjuvants Against Mycobacterium tuberculosis Infection.
IMMUNE NETWORK.
23,
2
(2023)
A nanoadjuvant that dynamically coordinates innate immune stimuli activation enhances cancer immunotherapy and reduces immune cell exhaustion.
NATURE NANOTECHNOLOGY.
18,
4
(2022)
Fabrication of Drug-Loaded Calcium Phosphate Nanoparticles: An Investigation of Microbial Toxicity.
JOURNAL OF CLUSTER SCIENCE.
33,
5
단행본
(2021)
Design of Nanostructure Materials to Modulate Immunosuppressive Tumour Microenvironments and Enhance Cancer Immunotherapy.
Springer Nature.
주저자
특허/프로그램
CRYOGEL SCAFFOLD CAPABLE OF CONTROLLING DEGREE OF DEGRADATION
AND SOFT BIO-INTEGRATED DEVICE IN WHICH DRUG MODULATING
IMMUNOSUPPRESSIVE ACTION IN SOLID MICROENVIRONMENT IS LOADED IN
SAME SCAFFOLD.
16/954,324.
20230112.
미국
톨-유사 수용체 7 또는 8 작용자와 콜레스테롤의 결합체 및 그 용도.
10-2020-0014775.
20211102.
대한민국
비동심 다중나노도메인 베시클 및 나노리포좀을 포함하는 비경구 약물전달용 가역적 겔, 및 이를 포함하는 약물전달용 조성물.
10-2020-0008381.
20211012.
대한민국
생체내 세포 투입칩을 유효성분으로 포함하는 항암용 약학조성물.
10-2019-0160276.
20210721.
대한민국
분해도 제어가 가능한 크라이오젤 스캐폴드 및 상기 스캐폴드에 고형암 미세환경에서 면역억제작용을 제어하는 약물을 로딩한 연성 생체삽입소자.
10-2018-0143015.
20210309.
대한민국
THERMOSENSITIVE IONIC COMPOSITE, PREPARING METHOD THEREOF, AND
BIODEGRADABLE COMPOSITION CONTAINING THE SAME.
14/828,876.
20180828.
미국
재구성 인공 암세포, 이의 제조방법, 및 이를 포함하는 항암조성물.
10-2017-0000357.
20180523.
대한민국
폴리감마글루탐산 함유 하이드로겔 및 이를 포함하는 의료용 접착제 및 지혈제.
10-2016-0026130.
20180427.
대한민국
약물 전달용 조성물 및 이의 제조방법.
10-2016-0116955.
20171201.
대한민국
약물전달 조성물, 및 감염질환 진단 및 치료용 조성물.
10-2015-0050833.
20161007.
대한민국
암 백신 조성물 및 이의 제조 방법.
10-2015-0050843.
20160804.
대한민국
생체친화성 음이온 고분자 기반 약물 전달용 조성물 및 이의 제조 방법.
10-2014-0112655.
20160802.
대한민국
아주번트 조성물 및 백신 조성물의 제조 방법.
10-2015-0073826.
20160215.
대한민국
면역보조제 및 이를 포함하는 백신 조성물.
10-2014-0195268.
20160112.
대한민국
면역자극 조성물, 이의 제조 방법, 및 이를 포함하는 면역요법 조성물.
10-2014-0195270.
20160112.
대한민국
아주번트 조성물, 이의 제조 방법, 및 이를 포함하는 백신 조성물.
10-2014-0193994.
20160112.
대한민국
아주번트 조성물, 이의 제조방법, 및 이를 포함하는 백신 조성물.
10-2014-0195269.
20151210.
대한민국
온도감응형 이온성 복합체, 이의 제조 방법, 및 이를 포함하는 생분해성 조성물.
10-2014-0107045.
20151116.
대한민국
중-대동물 수술가이드용 근적외선 형광 영상장비 및 이를 이용한 이미지화 및 수술가이드 방법.
1020130015119.
20150429.
대한민국
활성물질을 담지할 수 있는 표면 딤플구조를 갖는 미립자 및 그 제조방법.
1020130046966.
20141216.
대한민국
수상/공훈
국내외 화학관련 학회 정회원 (대한면역학회, 생체재료학회, 한국고분자학회 등)
대한면역학회 학술위원
국제학술지 Editorial Board
학술회의논문
(2024)
Engineered Novel Vaccine Adjuvant System.
1st International Symposium of PRIDE LaboratoryTowards One Health: Innovations in Infection and Inflammation.
대한민국
(2024)
Dynamic coordination of innate immune stimuli by nanoadjuvant enhances cancer immunotherapy without immune exhaustion.
Eighth CRI-ENCI International Cancer Immunotherapy Conference.
미국
(2024)
Programmed two-step activation of myeloid cells via antibody-adjuvant conjugates synergizes immune checkpoint blockade therapy with minimized systemic toxicity.
8th CRI-ENCI International Cancer Immunotherapy Conference.
미국
(2024)
Engineered nano-vaccines for prolonged and broad protection against heterologous variants of SARS-CoV-2 and influenza virus.
ibs-KAI-KSV Conferences on Infection and Immunity.
대한민국
(2024)
Dynamic immune modulation empowered by designer biomaterials.
WBC 2024, 12th World Biomaterials Congress.
대한민국
(2023)
Materials for kinetic immune modulation reshape immunity.
2023 International Conference of the Korean Society of Pharmaceutical Science and Technology.
대한민국
(2023)
Immune Designer for Dynamic Tailoring of Innate Immunity.
2023년 한국고분자학회 추계 정기총회 및 학술대회.
대한민국
(2023)
Dynamic Coordination of Innate Immunity for Enhanced Cancer Immunotherapy and Reduction of Immune Cell Exhaustion by Using Kinetically Activating Nanoadjuvant.
Seventh CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference.
이탈리아
(2023)
Dynamic Coordination of Innate Immunity for Enhanced Cancer Immunotherapy and Reduction of Immune Cell Exhaustion by Using Kinetically Activating Nanoadjuvant.
KAI International Meeting 2023.
대한민국
(2023)
Time-controled DC activation for enhanced cancer immunotherapy.
KAI International Meeting 2023.
대한민국
(2023)
Engineered Macrophages Anchored with Toll-like Receptor 7/8 Agonist by Click Chemistry Enhance Antitumor Immunity.
KAI International Meeting 2023.
대한민국
(2023)
Reprogramming TME with immunostimulator and blockade of SIRPα-CD47 axis enhances antitumor innate immunity.
KAI International Meeting 2023.
대한민국
(2023)
Designer Vaccine Adjuvant/immunomodulators for Injectious Disease.
대한바이러스 학회 연구회 연합 정기 학술대회.
대한민국
(2022)
Controlling Chemoimmunotherapy-induced Immunosuppression by Assemblable
Immune Modulating Nanosuspension Combined with Supra-adjuvant.
2022 한국생물공학회 추계학술발표대회 및 국제심포지엄.
대한민국
(2022)
Novel vaccine adjuvants empowered by coded signal integration.
바이러스연구포럼.
대한민국
(2022)
Nanoengineered Synthetic Immune Niches for Enhanced Cancer Immunotherapy.
2022 춘계고분자학술대회.
대한민국
(2021)
ENHANCED ANTI-CANCER EFFECT OF TOLL-LIKE RECEPTOR 7/8 AGONIST LOADED NANOEMULSION-BASED DELIVERY IN LUNG CANCER MODEL..
Bio-Inspired Nanomaterials.
대한민국
(2021)
In Situ Scaffold Forming Immunotherapeutic Nanogel Overcomes Post-Surgical Immunosuppressive Tumor Microenvironment And Generates Systemic Anti-Tumor Immunity.
Bio-Inspired Nanomaterials.
대한민국
(2021)
Reshaping Treatment-induced Immunosuppressive Tumor Microenvironment with Multifunctional Nanosuspension for Enhancing Chemo-Immunotherapy.
Bio-Inspired Nanomaterials.
대한민국
(2021)
Nanoengineered synthetic immune niches for the modulation of tumor immunosuppressive microenvironments in cancer immunotherapy.
2021 Nano Korea.
대한민국
발전기금
